I made quite a few cards and thought a bit about the mechanics that might be involved if they were in a real card game.
Your Hero:
Your Hero would probably be a head of a Pantheon like Zeus, Odin, etc. and they have a mana pool that is used to cast God abilities while they're on your board. I made the Mana Potion item as a showcase of how you could restore mana throughout a match.
The Gods:
You play Gods onto your board and they can attack enemy Gods. Not sure if I would want them to be able to attack the enemy Hero and that's how you win, similar to games like Magic or Hearthstone. Or if you would win by eliminating a certain number of enemy Gods like the Pokemon TCG. Either could work really.
The Items:
SMITE's items are an iconic part of the game so I wanted to include those as well. You can equip one item at once to any God on your board and they have an associated effect like Mystical Mail increasing health and dealing passive tick damage every turn to enemy Gods, or Heartseeker adding a % max health damage component to the wielding God's attacks.
The Game Modes (as location cards):
The game modes are also a big part of SMITE and I thought it would be fun to make Location Cards based on the modes such as Joust which limits both players' board size to 3 while its on the field as an homage to the game mode Joust in SMITE.
There's a ton more you could explore with a SMITE card game but this is just my attempt at spitballing some ideas and showcasing my (admittedly poor) graphic design skills in creating the cards!
Addendum: Didn't realize it had to be ONLY smite 2 Gods, disregard the Kuzenbo card*