Okay, so Equinox, is essentially a P.I Overhaul to a system that was enough to drive even stable people, slightly insane.
So now it's all about "division of labour" meaning the more people working together, the better the results and in keeping with Eve Online's No #1 motto "Risk vs reward" the lower sec you go with this, the more you make.
We are split into essentially 3 sets of work programs here
Power
Workforce
Reagents
Now, how does this help, well, because, you need to know that if you want to try and use Equinox systems, get some friends to help. Each of you can focus on a specific set of planets and the results will benefit all of you, in a much greater abundance.
Power Generation.
Whilst the new system allows "system-wide" - it is noted, that this cannot be exported or used in a system one jump over etc. So the more systems you spread over, the more work is needed.
Workforce Point.
This comes into focus with sovereignty hubs. provides human capital and this area can be used system to system, but again, it's a much more detailed system and requires research before you go down this route.
Reagents.
These are obtained from specific planets such as Lava and Ice Planets which will provide you with Magmatic Gas and Superionic Ice. These two are used essentially to fuel the SOV hubs and upgrades and of course the absolute need, the Metenox Moon Drill.
NOTE: These can be mined/gained/gathered, however you want to look at it for pure profit, can be moved system to system, region to region and of course can be hauled to Jita and sold for profit to other players.
NOTE: This stuff is not on the "easy to buy" list and should not be brought willy-nilly, you need to get IMO around 4 friends together, sit down, work out the costs, split it equally and work as a team in terms of who spends what on what item is needed.
NOTE: Teamwork is essential, if you try to do this on your own, you will give yourself a headache, it will become a chore and it will become a grind that you will end up hating yourself for.